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abstract::Heat stress on Madin-Darby canine kidney cells increased ceramide content to 187% at 40 degrees C for 24 h, and the de novo synthesis from serine increased to 146%. Glucosylceramide (GlcCer) and galactosylceramide (GalCer) synthesis from ceramide, the first glycosylation step of sphingolipid metabolism in kidney cells...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwq018
更新日期:2010-06-01 00:00:00
abstract::O-antigen (O-polysaccharide), a part of the outer membrane of Gram-negative bacteria, is one of the most variable cell constituents and is related to bacterial virulence. O-antigen diversity is almost entirely due to genetic variations in O-antigen gene clusters. In this study, the O-polysaccharide structures of Salmo...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwq015
更新日期:2010-06-01 00:00:00
abstract::The core oligosaccharide Glc(3)Man(9)GlcNAc(2) is assembled by a series of membrane-bound glycosyltransferases as the lipid carrier dolichylpyrophosphate-linked glycan in the endoplasmic reticulum (ER). The first step of this assembly pathway on the ER luminal side is mediated by ALG3 (asparagine-linked glycosylation ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwq028
更新日期:2010-06-01 00:00:00
abstract::The structures of the pectic polysaccharide rhamnogalacturonan II (RG-II) pectin constituent are remarkably evolutionary conserved in all plant species. At least 12 different glycosyl residues are present in RG-II. Among them is the seldom eight-carbon sugar 3-deoxy-d-manno-octulosonic acid (Kdo) whose biosynthetic pa...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwq011
更新日期:2010-05-01 00:00:00
abstract::N-Acetylglucosaminlyltransferase-V (GnT-V) synthesizes GlcNAcbeta1,6Man branched N-glycans both in vitro and in vivo. A paralog, GnT-Vb (or GnT-IX), has also been shown to synthesize both GlcNAcbeta1,6Man branched N- and O-glycans. GnT-V is expressed in most human and rodent tissues while GnT-Vb expression is limited ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp158
更新日期:2010-02-01 00:00:00
abstract::Sialidases are widely distributed glycohydrolytic enzymes removing sialic acid residues from glycoconjugates. In mammals, several sialidases with different subcellular localizations and biochemical features have been described. NEU4, the most recently identified member of the human sialidase family, is found in two fo...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp156
更新日期:2010-02-01 00:00:00
abstract::Changes in mucin protein expression and in glycosylation are common features in pre-neoplastic lesions and cancer and are therefore used as cancer-associated markers. De novo expression of intestinal mucin MUC2 and cancer-associated sialyl-Tn antigen are frequently observed in intestinal metaplasia (IM) and gastric ca...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp161
更新日期:2010-02-01 00:00:00
abstract::N-Acetylglucosaminyltransferase-IV (GnT-IV) has two isoenzymes, GnT-IVa and GnT-IVb, which initiate the GlcNAcbeta1-4 branch synthesis on the Manalpha1-3 arm of the N-glycan core thereby increasing N-glycan branch complexity and conferring endogenous lectin binding epitopes. To elucidate the physiological significance...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp200
更新日期:2010-01-01 00:00:00
abstract::Galbeta1-4GlcNAc is thought to be a common disaccharide unit preferentially recognized by vertebrate galectins. Eight-amino-acid residues conserved in proteins belonging to the galectin family have been suggested to be responsible for recognition. Meanwhile, we isolated and analyzed endogenous N-glycans of Caenorhabdi...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp125
更新日期:2009-12-01 00:00:00
abstract::Cancer-derived heat shock protein gp96 induces a tumor-specific protective immune response primarily mediated by cytotoxic T lymphocytes (CTL) directed toward cancer-associated peptides associated with gp96. Both innate and adaptive immune responses have been demonstrated using a cell culture-based signaling mechanism...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp096
更新日期:2009-12-01 00:00:00
abstract::Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis i...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp077
更新日期:2009-12-01 00:00:00
abstract::Galectins are a sub-family of lectins, defined by their highly conserved beta-sandwich structures and ability to bind to beta-galactosides, like Gal beta1-4 Glc (lactose). Here, we used (15)N-(1)H HSQC and pulse field gradient (PFG) NMR spectroscopy to demonstrate that galectin-1 (gal-1) binds to the relatively large ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp084
更新日期:2009-09-01 00:00:00
abstract::We have previously shown that varicella-zoster virus (VZV) and cytomegalovirus (CMV) infection of diploid human fibroblasts (HEL) results in neo-expression of Lewis antigens sialyl Lewis x (sLe(x)) and Lewis y (Le(y)), respectively, after transcriptional activation of different combinations of dormant human fucosyltra...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp057
更新日期:2009-08-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy which can cause acute quadriplegia. Infection with micro-organisms, including Campylobacter jejuni (C. jejuni), Haemophilus influenzae, and Cytomegalovirus (CMV), is recognized as a main triggering event for the disease. Lipooligosacchari...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwp027
更新日期:2009-07-01 00:00:00
abstract::We report here a method of simultaneously quantifying glucosylceramide (GlcCer) and galactosylceramide (GalCer) by normal-phase HPLC using O-phtalaldehyde derivatives. Treatment with sphingolipid ceramide N-deacylase which converts the cerebrosides in the sample to their lyso-forms was followed by the quantitative lab...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp047
更新日期:2009-07-01 00:00:00
abstract::Lens culinaris lectin (LCA) is a useful probe for the detection in serum of a core-fucosylated alpha-fetoprotein, called AFP-L3 fraction, which is a well-known marker for the diagnosis and prognosis of hepatocellular carcinoma. Here we performed a systematic quantitative interaction analysis of LCA and its close homol...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp016
更新日期:2009-05-01 00:00:00
abstract::Intelectin is an extracellular animal lectin found in chordata. Although human and mouse intelectin-1 recognize galactofuranosyl residues included in cell walls of various microorganisms, the physiological function of mammalian intelectin had been unclear. In this study, we found that human intelectin-1 was a serum pr...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwp013
更新日期:2009-05-01 00:00:00
abstract::Angiogenesis is associated with growth, invasion, and metastasis of human solid tumors. Aberrant activation of endothelial cells and induction of microvascular permeability by a vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) signaling pathway is observed in pathological angiogenesis including tumor, wo...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn114
更新日期:2009-03-01 00:00:00
abstract::The Malian medicinal plant Biophytum petersianum Klotzsch (Oxalidaceae) is used as a treatment against various types of illnesses related to the immune system, such as joint pains, inflammations, fever, malaria, and wounds. A pectic polysaccharide obtained from a hot water extract of the aerial parts of B. petersianum...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn090
更新日期:2008-12-01 00:00:00
abstract::The catabolism of dermatan sulfate (DS) commences with endohydrolysis of the polysaccharide to oligosaccharides by proposed endo-beta-N-acetylhexosaminidase and endohexuronidase activities. To investigate the substrate specificities of these activities, we developed an assay to measure specific products of their actio...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn097
更新日期:2008-12-01 00:00:00
abstract::Muscle degenerative diseases such as Duchenne Muscular Dystrophy are incurable and treatment options are still restrained. Understanding the mechanisms and factors responsible for muscle degeneration and regeneration will facilitate the development of novel therapeutics. Several recent studies have demonstrated that G...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn079
更新日期:2008-11-01 00:00:00
abstract::Affinities of the human blood group glycosyltransferases, alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) for their common acceptor substrate alpha-l-Fucp-(1-->2)-beta-d-Galp-O(CH2)(7)CH3 (1), in the absence and presence of bound uridine 5'-diphosphate (UDP) and Mn2+...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn043
更新日期:2008-08-01 00:00:00
abstract::Helicobacter pylori infects over half of the world's population and is thought to be a leading cause of gastric ulcer, gastric carcinoma, and gastric malignant lymphoma of mucosa-associated lymphoid tissue type. Previously, we reported that a gland mucin (MUC6) present in the lower portion of the gastric mucosa contai...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwn037
更新日期:2008-07-01 00:00:00
abstract::A common argument against using plants as a production system for therapeutic proteins is their inability to perform authentic N-glycosylation. A major concern is the presence of beta 1,2-xylose and core alpha 1,3-fucose residues on complex N-glycans as these nonmammalian N-glycan residues may provoke unwanted side ef...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm137
更新日期:2008-03-01 00:00:00
abstract::Shigella flexneri is a gram-negative bacterium responsible for serious enteric infections that occur mainly in the terminal ileum and colon. High interest in Shigella, as a human pathogen, is driven by its antibiotic resistance and the necessity to develop a vaccine against its infections. Vaccines of the last generat...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm140
更新日期:2008-03-01 00:00:00
abstract::It is widely reported that derivatives of sugar moieties can be used to metabolically label cell surface carbohydrates or inhibit a particular glycosylation. However, few studies address the effect of substitution of the cytidylmonophosphate (CMP) portion on sialyltransferase activities. Here we first synthesized 2'-O...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm132
更新日期:2008-02-01 00:00:00
abstract::We developed a new in vitro assay for oligosaccharyltransferase (OST), which catalyzes the transfer of preassembled oligosaccharides on lipid carriers onto asparagine residues in polypeptide chains. The asparagine residues reside in the sequon, Asn-X-Thr/Ser, where X can be any amino acid residue except Pro. We demons...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm087
更新日期:2007-11-01 00:00:00
abstract::The egg jellies of sea urchins contain sulfated polysaccharides with unusual structures, composed of linear chains of l-fucose or l-galactose with well-defined repetitive units. The specific pattern of sulfation and the position of the glycosidic bond vary among sulfated polysaccharides from different species. These p...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm058
更新日期:2007-08-01 00:00:00
abstract::Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm032
更新日期:2007-07-01 00:00:00
abstract::Murine sperm initiate fertilization by binding to the specialized extracellular matrix of their complementary eggs, known as the zona pellucida. On the basis of data reported in this study, mouse sperm also bind to rabbit erythrocytes with higher affinity than they do to murine eggs. This unusual interaction between a...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm025
更新日期:2007-06-01 00:00:00
abstract::Mammalian alpha1,6-fucosyltransferase (FUT8) catalyses the transfer of a fucose residue from a donor substrate, guanosine 5'-diphosphate-beta-L-fucose to the reducing terminal N-acetylglucosamine (GlcNAc) of the core structure of an asparagine-linked oligosaccharide. Alpha1,6-fucosylation, also referred to as core fuc...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl079
更新日期:2007-05-01 00:00:00
abstract::We have elucidated the carbohydrate-binding profile of a non-monosaccharide-binding lectin named Eucheuma serra lectin (ESA)-2 from the red alga Eucheuma serra using a lectin-immobilized column and a centrifugal ultrafiltration-high performance liquid chromatography method with a variety of fluorescence-labeled oligos...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm007
更新日期:2007-05-01 00:00:00
abstract::The human hyaluronidase Hyal-1, one of six human hyaluronidase subtypes, preferentially degrades hyaluronic acid present in the extracellular matrix of somatic tissues. Modulations of Hyal-1 expression have been observed in a number of malignant tumors. However, its role in disease progression is discussed controversi...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwm003
更新日期:2007-04-01 00:00:00
abstract::The human parasitic trematode Schistosoma mansoni has a complex life cycle that includes the freshwater snail Biomphalaria glabrata as intermediate host. Within each stage, the parasite synthesizes a wide array of glycoconjugates, exhibiting, in part, unique carbohydrate structures. In addition, the parasite expresses...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl048
更新日期:2007-01-01 00:00:00
abstract::The structure of asparagine-linked oligosaccharides attached to the antibody constant region (Fc) of human immunoglobulin G1 (IgG1) has been shown to affect the pharmacokinetics and antibody effector functions of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). However, it i...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl057
更新日期:2007-01-01 00:00:00
abstract::The structure of the complex mixture of the core oligosaccharide components of the lipooligosaccharide (LOS) fraction of Agrobacterium tumefaciens strain TT111 was determined directly on the deacetylated products by means of spectroscopical methods. The rhamnan oligosaccharide elongating the inner Kdo residue shares s...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl033
更新日期:2006-12-01 00:00:00
abstract::Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of ...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwl025
更新日期:2006-11-01 00:00:00
abstract::Viscumin of mistletoe (Viscum album L.) has a concentration-dependent activity profile unique to plant AB-toxins. It starts with lectin-dependent mitogenicity and then covers toxicity and cell agglutination, associated with shifts in the monomer/dimer equilibrium. Each lectin subunit harbors two sections for ligand co...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl017
更新日期:2006-10-01 00:00:00
abstract::The common O-glycan core structure in animal glycoproteins is the core 1 disaccharide Galbeta1-3GalNAcalpha1-Ser/Thr, which is generated by the addition of Gal to GalNAcalpha1-Ser/Thr by core 1 UDP-alpha-galactose (UDP-Gal):GalNAcalpha1-Ser/Thr beta1,3-galactosyltransferase (core 1 beta3-Gal-T or T-synthase, EC2.4.1.1...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwl008
更新日期:2006-10-01 00:00:00
abstract::Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are primarily localized in the plasma membrane. Cholera toxin B subunit (Ctxb), a component of a heat-labile enterotoxin produced by Vibrio cholerae, has been frequently used as a probe to detect GM1 ganglio...
journal_title:Glycobiology
pub_type: 信件
doi:10.1093/glycob/cwl003
更新日期:2006-09-01 00:00:00